About the Center for Deep Optical Imaging
Our Center was established on August 1, 2024, based on the funding termed Global Leader Project by the National Research Foundation in Korea.
The Center aims to develop optical methodologies for imaging, sensing, and light manipulation of targets located deep within scattering media with their working depth beyond the level of conventional approaches. In particular, we are determined to solve inverse scattering problems at the microscopic level of scattering events and understand the physics of wave propagation inside scattering media. At the same time, we are seeking to apply the developed methods for interrogating important biological and biomedical problems.
Breakthroughs Made Over the Past Decade
Our Center has been addressing one of the most important and challenging problems in the history of optical imaging—probing targets embedded deep within a scattering medium. We have systematically approached this subject, progressively solving low- to high-order inverse scattering problems. Through these efforts, we have pioneered a novel imaging framework termed Reflection Matrix Imaging (RMI), achieving non-invasive optical imaging with high resolution at unprecedented imaging depths. We have also reported other noteworthy results, including the control of wave propagation in scattering media, the study of wave propagation in scattering media, and the development of transformative imaging modalities such as a lensless single-fiber endoscope, which has reinforced progress in deep-tissue imaging.
Representative Reports
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Deep imaging within a complex medium
- Tracing multiple scattering trajectories for deep optical imaging in scattering media
(Nature Communications 14, 6871 (2023))
- Label-free adaptive optics single-molecule localization microscopy for whole zebrafish
(Nature Communications 14, 4185 (2023))
- Exploiting volumetric wave correlation for enhanced depth imaging in scattering medium
(Nature Communications 14, 1878 (2023))
- Computational conjugate adaptive optics for longitudinal through-skull imaging of cortical myelin
(Nature Communications 14, 105 (2023))
- Through-skull brain imaging in vivo at visible wavelengths via dimensionality reduction adaptive-optical microscopy (Science Advances 8, eabo4366 (2022))
- High-throughput volumetric adaptive optical imaging using compressed time-reversal matrix
(Light: Science & Applications 11,16 (2022))
- Laser scanning reflection-matrix microscopy for aberration-free imaging through intact mouse skull
(Nature Communications 11, 5721 (2020))
- Deep tissue space-gated microscopy via acousto-optic interaction (Nature Communications 11, 710 (2020))
- Deep optical imaging within complex scattering media (Nature Reviews Physics 2, 141 (2020))
- Label-free neuroimaging in vivo using synchronous angular scanning microscopy with single-scattering accumulation algorithm (Nature Communications 10, 3152 (2019))
- High-resolution adaptive optical imaging within thick scattering media using closed-loop accumulation of single scattering (Nature Communications 8, 2157 (2017))
- Imaging deep within a scattering medium using collective accumulation of single-scattered waves
(Nature Photonics 9, 253 (2015))
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Understanding/exploiting wave propagation within/through a complex medium
- Measuring the scattering tensor of a disordered nonlinear medium (Nature Physics 19, 1709 (2023))
- Wave propagation dynamics inside a complex scattering medium by the temporal control of backscattered waves (Optica 10, 569 (2023))
- Focusing of light energy inside a scattering medium by controlling the time-gated multiple light scattering
(Nature Photonics 12, 277 (2018))
- Measurement of the time-resolved reflection matrix for enhancing light energy delivery into a scattering medium (Physical Review Letters 111, 243901 (2013))
- Maximal energy transport through disordered media with the implementation of transmission eigenchannels
(Nature Photonics 6, 581 (2012))
- Transmission eigenchannels in a disordered medium (Physical Review B 83, 134207 (2011))
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Matrix approaches for endoscopy and nanoscopy
- Flexible-type ultrathin holographic endoscope for microscopic imaging of unstained biological tissues
(Nature Communications 13, 4469 (2022))
- Near-field transmission matrix microscopy for mapping high-order eigenmodes of subwavelength nanostructures (Nature Communications 11, 2575 (2020))
- Control of randomly scattered surface plasmon polaritons for multiple-input and multiple-output plasmonic switching devices (Nature Communications 8, 14636 (2017))
- Scanner-free and wide-field endoscopic imaging by using a single multimode optical fiber
(Physical Review Letters 109, 203901 (2012); Editor’s suggestion and highlighted with a viewpoint;
Research highlights in Nature 491, 641 (2012))
- Overcoming the diffraction limit using multiple light scattering in a highly disordered medium
(Physical Review Letters 107, 023902 (2011))
Announcements
Our center is actively recruiting graduate students and postdoctoral researchers interested in optical microscopy, deep optical imaging, computational imaging with machine learning/deep learning, and optical computing. We are also open to undergraduate internship applicants, not only from the Department of Physics at Korea University but also from other universities and departments. Interested individuals are encouraged to contact us at wonshik@korea.ac.kr.
Center for Deep Optical Imaging
Phone. +82-2-3290-3118
Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul 02841, Korea, 02841